COVID 19 Vaccine Trials: Scientist Warns Against Fast-Tracking

COVID 19 Vaccine
COVID 19 Vaccine

COVID 19 Vaccine Trials: Scientist Warns Against Fast-Tracking

COVID 19 Vaccine trials that have been progressing successfully, and at one promising therapeutic approach for COVID-19: Convalescent plasma therapy.

Scientists around the globe are working to develop an effective COVID 19 Vaccine.

Although a COVID-19 vaccine is urgent, scientists cannot rush the development process. In a recent editorial, immunologist and deputy editor of the journal Science Advances Dr. Douglas J. Green explains why bypassing essential clinical trial stages for any such vaccine could be ‘catastrophic.’

Until such a time, the world is reliant on physical distancing measures and personal protective equipment (PPE). Some countries are using ‘track and trace’ systems to monitor the movements of people and notify those who have been in contact with somebody diagnosed with COVID-19.

The COVID 19 Vaccine Development Process

Currently, there are 95 COVID 19 Vaccine under development. After the discovery and pre-clinical development stages, each of these must progress through three phases of clinical trials.

Phase I involves safety testing in a small cohort (e.g., 10–50 people). Phase II trials involve investigating the immune response in a larger cohort.

Phase III trials involve much larger groups of people (sometimes in the thousands) and must show, in a statistically significant manner, that the vaccine can protect against infection. This stage alone can take several years under normal circumstances.

A COVID-19 vaccine may come without a needle, the latest vaccine to protect  without jabbing

Slow is fast

As well as the scientific roadblocks, there are many ethical hurdles to overcome before performing studies of experimental vaccines in people; studies that may pose significant risks. Dr. Green says that scientists must way up these “extreme risks” against the potential benefits.

The take-home message of the article is that while time is of the essence, it is essential to ensure the safety of any potential vaccine.

It is vital to ensure the safety of any vaccine, including a full investigation of its potential adverse effects. Rushing this process could have catastrophic consequences, says Dr. Green, who recommends the application of the axiom ‘Fast is slow, and slow is fast’ to COVID 19 Vaccine development.

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